Propylene glycol has been reported to cause lactic acidosis after overdose. In some cases hemodialysis has been used.
Treatment of ethylene glycol toxicity is with ethanol, which inhibits alcohol dehydrogenase, fomepizole, which also inhibits alcohol dehydrogenase, and bicarbonate to treat acidosis. A renal biopsy showed tubular oxalate deposits. A CT scan of the brain showed low-density areas in the bilateral basal ganglia, midbrain, and pons. Acute oliguric renal failure required continuous hemodialysis for 6 days. There was a severe metabolic acidosis with a wide anion gap and many crystals in the urinary sediment. He vomited, lost consciousness, and had miosis and external ophthalmoplegia. Ī 36-year-old long-distance truck driver took 200 ml of ethylene glycol in a suicide attempt.Hemorrhage in the globus pallidus occurred in a 50-yearold Afro-Caribbean alcoholic man after ethylene glycol poisoning there was evidence of lactic acidosis and the ethylene glycol concentration was 6.06 mmol/l. Ethylene glycol poisoning can cause acidosis, central nervous system depression, pulmonary edema, acute oliguric renal failure with crystalluria, liver damage due to calcium oxalate deposition, nausea, abdominal pain, and cramping, acute colonic ischemia, and papilledema and abducens nerve palsy.
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